Comparison of Haloperidol and Chlorpromazine in the Treatment of Phencyclidine Psychosis
A. James Giannini, Michael S. Eighan, Robert H. Loiselle, Matthew C. Giannini
The Journal of Clinical Pharmacology April 1, 1984 DOI: 10.1002/j.1552-4604.1984.tb01831.x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Comparative study Peer reviewed |
|---|---|
| Population | Human populations |
| Interventions | Haloperidol Chlorpromazine |
| Key points | Haloperidol and chlorpromazine are both effective in treating PCP psychosis, but their relative effects in humans had not been compared before this study. |
Abstract
Two neuroleptics, haloperidol and chlorpromazine, have been reported to be effective in the treatment of phencyclidine (PCP) psychosis. Both neuroleptics are thought to exert their antipsychotic PCP effects by blockade of central dopamine receptors. They have been studied extensively in animal populations and less extensively in human populations. There has, however, been no comparison of their relative effects in human populations. We describe such a study below.
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