A rat model of phencyclidine psychosis.
S Ogawa, S Okuyama, H Araki, A Nakazato, S Otomo
Life Sciences 1994 DOI: 10.1016/0024-3205(94)00326-2 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal model Peer reviewed |
|---|---|
| Population | Rats |
| Intervention | Phencyclidine (PCP) |
| Key points | Low doses of PCP impaired rats' performance in water maze and diving tasks without producing stereotyped behavior or hyperlocomotion. |
Abstract
Phencyclidine (PCP)-induced behavior in rats was investigated in water maze and diving behavior tasks. The swimming and diving latencies of PCP-treated groups placed in a water maze apparatus were gradually shortened, and prolonged, respectively, while rats in a control group performed well. In all rats, stereotyped behavior and hyperlocomotion were absent. We propose that this animal model induced by lower doses of PCP may be useful for further studies to research schizophrenia.
Citations in the library
Cited by 5
- Positive association of phencyclidine-responsive genes, PDE4A and PLAT, with schizophrenia. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics December 2011
- The effects of phencyclidine (PCP) on anxiety-like behavior in the elevated plus maze and the light-dark exploration test are age dependent, sexually dimorphic, and task dependent. Pharmacology, Biochemistry, and Behavior November 1, 2011
- Cannabinoid receptor antagonists counteract sensorimotor gating deficits in the phencyclidine model of psychosis. Neuropsychopharmacology October 1, 2007
- Phencyclidine in the social interaction test: an animal model of schizophrenia with face and predictive validity. Reviews in the Neurosciences 1999
- Effects of phencyclidine on immediate early gene expression in the brain. Journal of Neuroscience Research July 1, 1996
Cites 3
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