A rat model of phencyclidine psychosis.
S Ogawa, S Okuyama, H Araki, A Nakazato, S Otomo
Life Sciences 1994 DOI: 10.1016/0024-3205(94)00326-2 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal model Peer reviewed |
|---|---|
| Population | Rats |
| Intervention | Phencyclidine (PCP) |
| Key points | Low doses of PCP impaired rats' performance in water maze and diving tasks without producing stereotyped behavior or hyperlocomotion. |
Abstract
Phencyclidine (PCP)-induced behavior in rats was investigated in water maze and diving behavior tasks. The swimming and diving latencies of PCP-treated groups placed in a water maze apparatus were gradually shortened, and prolonged, respectively, while rats in a control group performed well. In all rats, stereotyped behavior and hyperlocomotion were absent. We propose that this animal model induced by lower doses of PCP may be useful for further studies to research schizophrenia.