Delayed changes in neural visinin-like calcium-binding protein gene expression caused by acute phencyclidine administration.
Y Kajimoto, O Shirakawa, T Kuno, N Nishino, H Nakai
Journal of neural transmission. General section 1995 DOI: 10.1007/bf01276463 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal study Peer reviewed |
|---|---|
| Population | Rats |
| Intervention | Phencyclidine (PCP) |
| Duration | 24 hours |
| Key points | PCP reduced NVP-1 mRNA levels in the nucleus accumbens by 42% after 24 hours. |
Abstract
Phencyclidine (PCP) induces a psychotomimetic state that closely resembles schizophrenia, and PCP-treated animals can serve as a model for schizophrenia. The effects of PCP on the gene expression of NVP-1, a novel Ca(2+)-binding protein, were studied in rats. After 24 hours, the NVP-1 mRNA level in the nucleus accumbens showed a significant decrease of 42%. This result suggests that alterations in Ca(2+)-binding protein may be involved in the pathology of PCP-induced psychosis and, presumably, schizophrenia.