Chronic phencyclidine administration induces schizophrenia-like changes in N-acetylaspartate and N-acetylaspartylglutamate in rat brain.
Lindsay M Reynolds, Susan M Cochran, Brian J Morris, Judith A Pratt, Gavin P Reynolds
Schizophrenia Research March 1, 2005 DOI: 10.1016/j.schres.2004.02.003 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Population | Rats |
| Intervention | Phencyclidine (PCP) |
| Duration | Chronic intermittent regime |
| Key findings | Chronic intermittent PCP administration in rats produced NAA and NAAG deficits only in the temporal cortex and elevated NAAG in the hippocampus, closely reflecting postmortem findings in schizophrenia. |
Abstract
Administration of phencyclidine (PCP) to both humans and animals models the symptoms of schizophrenia. Brain concentrations of N-acetylaspartate (NAA) are reduced in this disease, reflecting neuronal dysfunction. This study investigates the effects in rats of a chronic intermittent regime of PCP on NAA and its precursor N-acetylaspartylglutamate (NAAG) in rat frontal and temporal cortex, hippocampus and striatum, determined by HPLC. We found significant PCP-induced deficits of NAA and NAAG only in the temporal cortex; NAAG was significantly elevated in the hippocampus. These changes closely reflect postmortem findings reported in schizophrenia.
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- The subchronic phencyclidine rat model: relevance for the assessment of novel therapeutics for cognitive impairment associated with schizophrenia. Psychopharmacology November 2015
- Effects of subchronic phencyclidine on behaviour of female rats on the elevated plus maze and open field. Journal of Psychopharmacology May 2010
- Schizophrenia-like GABAergic gene expression deficits in cerebellar Golgi cells from rats chronically exposed to low-dose phencyclidine. Neurochemistry International December 2009
- T-817MA, a novel neurotrophic compound, ameliorates phencyclidine-induced disruption of sensorimotor gating. Psychopharmacology April 2008
and 2 more in the library
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