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Personality, prior drug use, and introspective experience during nitrous oxide intoxication.

R M Atkinson, J D Green

International Journal of the Addictions July 1, 1983 DOI: 10.3109/10826088309027365 (opens in new tab)

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Characteristics Observational cohort Peer reviewed
Sample size 60
Population Young men
Intervention Nitrous oxide-oxygen mixture
Dose 40% nitrous oxide-oxygen mixture
Duration 20 min
Key findings Openness to reverie-type experiences was strongly related to a wide variety of drug responses, while introversion, neuroticism, and openness to nonreverie mental experiences were not.

Abstract

This report compares data on some personality characteristics and prior drug experiences of 60 volunteer young men with their subjective psychological responses while inhaling 40% nitrous oxide-oxygen mixtures for 20 min in a naturalistic laboratory setting. A rather specific trait-openness to "internal," reverie-type experiences-was very significantly related to a wide variety of drug responses, while several more general traits-including introversion and neuroticism-and openness to nonreverie mental experiences were unrelated to drug response. Prior illicit drug use was related only to mood on nitrous oxide, and not to other effects. Implications of the findings in the field of drug abuse are discussed.

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