Psicosis inducida por cannabis: características clínicas y su diferenciación con la esquizofrenia con y sin consumo de cannabis asociado
David Rentero Martín, F. Árias, Sergio Sánchez-Romero, Gabriel Rubio, Roberto Rodríguez–Jiménez
Adicciones July 14, 2020 DOI: 10.20882/adicciones.1251 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Sample size | 307 |
| Population | Inpatients with psychosis |
| Topics | Cannabis CBD |
| Keywords | Psychosis Schizophrenia object-oriented programming Mania Effects of cannabis Bipolar disorder Cognition |
| Citations | 13 |
| Key findings | Cannabis use was associated with earlier first admission for psychosis, and cannabis-induced psychosis patients showed fewer negative symptoms and more mania than schizophrenia patients with cannabis use. |
Abstract
Cannabis use is considered an established risk factor for psychosis development. Differentiating between cannabis-induced disorders and schizophrenia is useful for prognostic and therapeutic purposes. Three inpatients groups were differentiated: cannabis-induced psychosis (CIP) (n = 69; mean age = 27.4, SD = 6.5; 82.6% males), schizophrenia with cannabis abuse or dependence (SZ + CB) (n = 57; mean age = 31.9, SD = 10.1; 94.7% males) and schizophrenia without cannabis abuse or dependence (SZ) (n = 181; mean age = 41.8, SD = 13.3; 54.1% males). The Psychiatric Research Interview for Substance and Mental Disorders (PRISM-IV) scale was used to differentiate induced psychosis. The CIP group presented lower mean scores on the negative PANSS subscale (M = 12.9, SD = 5.9; F = 32.24, p < 0.001), fewer auditory hallucinations (60.3%; X² = 6.60, p = 0.037) and greater presence of mania (26.1% vs. 12.3%; X² = 32.58, p < 0.001) than the SZ + CB group. There were few clinical differences between patients with schizophrenia, regardless of previous cannabis use. The age of first admission due to psychosis was lower in both psychotic inpatients groups with cannabis use (M = 26.1, SD = 6.4 in CIP and M = 25.3, SD = 6.2 in SZ + CB; X² = 20.02, p < 0,001). A clinical pattern characteristic of cannabis-induced psychosis was not observed, but the precipitating role of cannabis in the appearance of psychotic symptoms was demonstrated, given the lower age of first admission due to psychosis in cannabis user groups.
Comparable studies
Other observational and cohort studies on cannabis, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| High-potency cannabis and the risk of psychosis People with first episode of psychosis and healthy controls from the local population | 2009 | Case-control study | n = 454 |
| Ayahuasca-Assisted Therapy for Addiction: Results from a Preliminary Observational Study in Canada Rural aboriginal population | 2013 | Observational study | |
| Impaired cognitive performance in drug free users of recreational ecstasy (MDMA) Otherwise healthy young people | 2000 | Observational | |
| Continued cannabis use and risk of incidence and persistence of psychotic symptoms: 10 year follow-up cohort study Individuals from the general population in Germany aged 14-24 at baseline | 2011 | Observational cohort | n = 1,923 |
| Cannabis-induced psychosis and subsequent schizophrenia-spectrum disorders: follow-up study of 535 incident cases Patients treated for cannabis-induced psychotic symptoms in Denmark between 1994 and... | 2005 | Observational cohort | n = 535 |
Citations in the library
Cited by 5
- Cannabis Use and Psychosis – Modern Views on the Problem. Narrative Synthesis Medicina 2021
- O uso de Cannabis como fator de risco para o desenvolvimento/progressão de quadros de Esquizofrenia: Uma revisão de literatura Research, Society and Development November 4, 2023
- Clinical and Sociodemographic Characteristics of Young People With Early Psychosis: Comparing Cannabis Users and Non‐Users in a Specialized Early Intervention Setting Early Intervention in Psychiatry August 1, 2026
- Cannabis and Psychosis: An Overview of The Relationship Revista Portuguesa de Psiquiatria e Saúde Mental September 30, 2023
- The why behind the high: determinants of neurocognition during acute cannabis exposure. Nature Reviews Neuroscience July 1, 2021
Cites 10
- Effects of cannabis use on outcomes of psychotic disorders: systematic review The British Journal of Psychiatry October 31, 2008
- Cannabis-induced psychosis and subsequent schizophrenia-spectrum disorders: follow-up study of 535 incident cases The British Journal of Psychiatry November 30, 2005
- Cannabis use and first-episode psychosis: relationship with manic and psychotic symptoms, and with age at presentation Psychological Medicine May 24, 2013
- Consumo de cannabis y alteraciones cognitivas en esquizofrenia y primeros episodios psicóticos Adicciones April 1, 2019
- Cannabis psychosis: examining the evidence for a distinctive psychopathology in a systematic and narrative review. American Journal on Addictions November 1, 2012
and 5 more in the library