N,N-Diisopropyltryptamine and diptogenia: proposed mechanisms for a frequency-selective pitch-distorting psychedelic.
Aidan Hurst, Victoria M Bajo
Brain Communications 2026 DOI: 10.1093/braincomms/fcag093 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Theoretical or philosophical paper Peer reviewed |
|---|---|
| Interventions | N N-Diisopropyltryptamine (DiPT) |
| Post-publication review | 2 comments on PubPeer (opens in new tab) · last active June 2026 |
| Key points | Proposes that the pitch-distorting effects of DiPT may be harnessed as a potential treatment for tinnitus. |
Abstract
N,N-Diisopropyltryptamine (DiPT) is a frequency-selective pitch-distorting psychedelic drug that induces a downward shift in perception where the auditory world of the subject sounds lower in pitch than in a sober state of consciousness. Hurst and Bajo propose the neural mechanisms for this effect and its use as potential therapeutic for tinnitus.
Citations in the library
Cites 4
- Psychedelics and the Human Receptorome PLoS One 2010
- Dimethyltryptamine and other hallucinogenic tryptamines exhibit substrate behavior at the serotonin uptake transporter and the vesicle monoamine transporter. Journal of Neural Transmission September 12, 2009
- Pharmañopo-psychonautics: human intranasal, sublingual, intrarectal, pulmonary and oral pharmacology of bufotenine. Journal of Psychoactive Drugs 2001
- Tolerance and cross-tolerance to head twitch behavior elicited by phenethylamine- and tryptamine-derived hallucinogens in mice. Journal of Pharmacology and Experimental Therapeutics December 1, 2014