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N,N-Diisopropyltryptamine and diptogenia: proposed mechanisms for a frequency-selective pitch-distorting psychedelic.

Aidan Hurst, Victoria M Bajo

Brain Communications 2026 DOI: 10.1093/braincomms/fcag093 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Theoretical or philosophical paper Peer reviewed
Interventions N N-Diisopropyltryptamine (DiPT)
Post-publication review 2 comments on PubPeer (opens in new tab) · last active June 2026
Key points Proposes that the pitch-distorting effects of DiPT may be harnessed as a potential treatment for tinnitus.

Abstract

N,N-Diisopropyltryptamine (DiPT) is a frequency-selective pitch-distorting psychedelic drug that induces a downward shift in perception where the auditory world of the subject sounds lower in pitch than in a sober state of consciousness. Hurst and Bajo propose the neural mechanisms for this effect and its use as potential therapeutic for tinnitus.