Psychotropic Effects of Cannabis
Ivan A. Ross
Plant-Based Therapeutics, Volume 1 2023 DOI: 10.1007/978-3-031-35155-6_6 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | Cannabis |
| Key findings | Delta-9-tetrahydrocannabinol can disrupt neurodevelopment by interacting with endocannabinoid signaling through cannabinoid receptors. |
Abstract
Brain development is a complex phenomenon from fetal life to adolescence. During this period, the brain’s maturation proceeds through a series of ordered events, including critical periods of plasticity. The brain is particularly sensitive to the environment during the changes. The endocannabinoid system participates directly and indirectly in the plasticity and maturation processes. The main psychoactive component of Cannabis , delta-9-tetrahydrocannabinol, can cross the placental barrier; it is present in breast milk and diffuses in the brain; it interacts with endocannabinoid signaling, especially through activating cannabinoid receptors which can lead to abnormal neurodevelopmental processes and the functions of neuronal circuits [1].
Comparable studies
Other narrative reviews on cannabis, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Causal association between cannabis and psychosis: examination of the evidence | 2004 | Review | |
| Cannabis sativa: A comprehensive ethnopharmacological review of a medicinal plant with a long history. General (historical and pharmacological review) | 2018 | Review | |
| Psychiatric effects of cannabis | 2001 | Review | |
| Beyond THC: The New Generation of Cannabinoid Designer Drugs | 2011 | Review | |
| Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug | 2006 | Review |
Citations in the library
Cites 39
- Distinct Effects of Δ9-Tetrahydrocannabinol and Cannabidiol on Neural Activation During Emotional Processing Archives of General Psychiatry 2009
- Traditional marijuana, high‐potency cannabis and synthetic cannabinoids: increasing risk for psychosis World Psychiatry September 22, 2016
- Continued cannabis use and risk of incidence and persistence of psychotic symptoms: 10 year follow-up cohort study BMJ March 1, 2011
- Modulation of Mediotemporal and Ventrostriatal Function in Humans by Δ9-Tetrahydrocannabinol Archives of General Psychiatry April 1, 2009
- COMT Val158Met moderation of cannabis‐induced psychosis: a momentary assessment study of ‘switching on’ hallucinations in the flow of daily life Acta Psychiatrica Scandinavica September 19, 2008
and 34 more in the library