Affective Switch Associated With Oral, Low Dose Ketamine Treatment in a Patient With Treatment Resistant Bipolar I Depression. Case Report and Literature Review
Alina Wilkowska, Łukasz P. Szałach, Jakub Słupski, Aleksandra Wielewicka, Małgorzata Czarnota, Maria Gałuszko‐węgielnik, Mariusz S. Wiglusz, Wiesław Jerzy Cubała
Frontiers in Psychiatry June 3, 2020 DOI: 10.3389/fpsyt.2020.00516 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case study Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | Bipolar I disorder patient with treatment-resistant depressive episode |
| Intervention | oral ketamine |
| Dose | subanaesthetic doses |
| Topics | Depression Ketamine Esketamine |
| Keywords | Bipolar disorder Depression economics Depressive symptoms Mania Lithium medication Cognition |
| Citations | 9 |
| Key findings | A patient with bipolar I disorder experienced a switch to a manic episode with mixed features after receiving eight subanaesthetic doses of oral ketamine as an add-on treatment. |
Abstract
There is a growing evidence for the rapid and robust antidepressive effect of ketamine in unipolar and bipolar treatment resistant depression although evidence for the risk of affective switch is still limited. This case presents bipolar I disorder patient with treatment resistant depressive episode experiencing a switch to manic episode with mixed features shortly after receiving eight subanaesthetic doses of oral ketamine as an add-on treatment preceded by 2-day period of manic symptoms.
Comparable studies
Other case reports and case series on ketamine for depression, most cited first.
Citations in the library
Cited by 7
- Real-world effectiveness of ketamine in treatment-resistant depression: A systematic review & meta-analysis. Journal of Psychiatric Research May 1, 2022
- Intravenous Ketamine Infusions in Treatment-Resistant Bipolar Depression: An Open-Label Naturalistic Observational Study Neuropsychiatric Disease and Treatment August 1, 2021
- Central nervous system-related safety and tolerability of add-on ketamine to standard of care treatment in treatment-resistant psychotic depression in patients with major depressive disorder and bipolar disorder Frontiers in Neuroscience July 11, 2023
- Psychotomimetic compensation versus sensitization. Pharmacology Research & Perspectives August 1, 2024
- Polish standard of treatment with racemic ketamine for patients with depressive disorders developed by a Working Group appointed by the National Consultant in the field of psychiatry. Psychiatria Polska June 30, 2024
and 2 more in the library
Cites 8
- Rapid Resolution of Suicidal Ideation After a Single Infusion of anN-Methyl-D-Aspartate Antagonist in Patients With Treatment-Resistant Major Depressive Disorder The Journal of Clinical Psychiatry July 13, 2010
- Impact of oral ketamine augmentation on hospital admissions in treatment-resistant depression and PTSD: a retrospective study. Psychopharmacology February 1, 2018
- Induction of Prolonged Mania During Ketamine Therapy for Reflex Sympathetic Dystrophy Biological Psychiatry May 6, 2011
- Mania following ketamine abuse. Neuropsychiatric Disease and Treatment 2016
- Ketamine-Induced Mania During Treatment for Complex Regional Pain Syndrome Pain Medicine March 10, 2017
and 3 more in the library