Breakdown of long-range temporal dependence in default mode and attention networks during deep sleep
Enzo Tagliazucchi, Frederic von Wegner, Astrid Morzelewski, Verena Brodbeck, Kolja Jahnke, Helmut Laufs
Proceedings of the National Academy of Sciences September 3, 2013 DOI: 10.1073/pnas.1312848110 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Population | Human participants across the nonrapid eye movement sleep cycle |
| Topics | Default mode network Addiction |
| Keywords | Wakefulness Sleep system call Eye movement Slow-wave sleep Property philosophy Cognitive psychology Cognition Electroencephalography |
| Citations | 278 |
| Key findings | Long-range temporal dependence in neural activity decreases from wakefulness to deep nonrapid eye movement sleep, especially in default mode and attention networks. |
Abstract
The integration of segregated brain functional modules is a prerequisite for conscious awareness during wakeful rest. Here, we test the hypothesis that temporal integration, measured as long-term memory in the history of neural activity, is another important quality underlying conscious awareness. For this aim, we study the temporal memory of blood oxygen level-dependent signals across the human nonrapid eye movement sleep cycle. Results reveal that this property gradually decreases from wakefulness to deep nonrapid eye movement sleep and that such decreases affect areas identified with default mode and attention networks. Although blood oxygen level-dependent spontaneous fluctuations exhibit nontrivial spatial organization, even during deep sleep, they also display a decreased temporal complexity in specific brain regions. Conversely, this result suggests that long-range temporal dependence might be an attribute of the spontaneous conscious mentation performed during wakeful rest.
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| Assessment of addiction severity among ritual users of ayahuasca Regular ayahuasca users (jungle-based and urban-based) and matched controls | 2010 | Observational cohort | n = 127 |
| Treatment of opioid use disorder with ibogaine: detoxification and drug use outcomes. Adults with DSM-IV opioid dependence | 2018 | Observational study | n = 30 |
Citations in the library
Cited by 46
- Human consciousness is supported by dynamic complex patterns of brain signal coordination Science Advances February 1, 2019
- Enhanced repertoire of brain dynamical states during the psychedelic experience Human Brain Mapping July 3, 2014
- The spectral exponent of the resting EEG indexes the presence of consciousness during unresponsiveness induced by propofol, xenon, and ketamine Neuroimage January 11, 2019
- How do the brain's time and space mediate consciousness and its different dimensions? Temporo-spatial theory of consciousness (TTC). Neuroscience & Biobehavioral Reviews September 1, 2017
- Is the self a higher-order or fundamental function of the brain? The "basis model of self-specificity" and its encoding by the brain's spontaneous activity. Cognitive Neuroscience 2016
and 41 more in the library
Cites 11
- A default mode of brain function Proceedings of the National Academy of Sciences January 16, 2001
- Resting-State Functional Connectivity Reflects Structural Connectivity in the Default Mode Network Cerebral Cortex April 9, 2008
- Consciousness as Integrated Information: a Provisional Manifesto Biological Bulletin December 1, 2008
- Patterns of Brain Activity Supporting Autobiographical Memory, Prospection, and Theory of Mind, and Their Relationship to the Default Mode Network Journal of Cognitive Neuroscience July 6, 2009
- Decoupling of the brain's default mode network during deep sleep Proceedings of the National Academy of Sciences June 19, 2009
and 6 more in the library