Chronic Neuropathic Pain and Comorbid Depression Syndrome: From Neural Circuit Mechanisms to Treatment.
Yue Zhang, Hui Ma, Yafan Bai, Xiaojuan Hou, Yixin Yang, Guyan Wang, Yunfeng Li
ACS Chemical Neuroscience July 3, 2024 DOI: 10.1021/acschemneuro.4c00125 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Intervention | ketamine |
| Topics | Depression |
| Keywords | Chronic neuropathic pain Neural circuit Chronic-pain Mental-health Brain-research Pain-depression-link |
| Citations | 25 |
| Key findings | Activating certain neural circuits can alleviate pain or depression, while activating others can exacerbate these conditions in chronic neuropathic pain and comorbid depression syndrome. |
Abstract
Chronic neuropathic pain and comorbid depression syndrome (CDS) is a major worldwide health problem that affects the quality of life of patients and imposes a tremendous socioeconomic burden. More than half of patients with chronic neuropathic pain also suffer from moderate or severe depression. Due to the complex pathogenesis of CDS, there are no effective therapeutic drugs available. The lack of research on the neural circuit mechanisms of CDS limits the development of treatments. The purpose of this article is to provide an overview of the various circuits involved in CDS. Notably, activating some neural circuits can alleviate pain and/or depression, while activating other circuits can exacerbate these conditions. Moreover, we discuss current and emerging pharmacotherapies for CDS, such as ketamine. Understanding the circuit mechanisms of CDS may provide clues for the development of novel drug treatments for improved CDS management.
Comparable studies
Other narrative reviews on depression, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Synaptic Dysfunction in Depression: Potential Therapeutic Targets | 2012 | Review | |
| Mindfulness-Based Cognitive Therapy for Depression: A New Approach to Preventing Relapse | 2003 | Review | |
| Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression: An International Expert Opinion on the Available Evidence and Implementation Adults with treatment-resistant depression | 2021 | Review | |
| Classic psychedelics: An integrative review of epidemiology, therapeutics, mystical experience, and brain network function. General population | 2019 | Integrative review | |
| Sudarshan Kriya Yogic Breathing in the Treatment of Stress, Anxiety, and Depression: Part II—Clinical Applications and Guidelines | 2005 | Review |
Citations in the library
Cites 9
- Optogenetic stimulation of infralimbic PFC reproduces ketamine’s rapid and sustained antidepressant actions Proceedings of the National Academy of Sciences June 8, 2015
- Sustained antidepressant effect of ketamine through NMDAR trapping in the LHb Nature October 18, 2023
- The dissociative and analgesic properties of ketamine are independent Anesthesiology September 4, 2020
- The PrLGlu→avBNSTGABA circuit rapidly modulates depression-like behaviors in male mice. iScience October 20, 2023
- TIAM1-mediated synaptic plasticity underlies comorbid depression–like and ketamine antidepressant–like actions in chronic pain Journal of Clinical Investigation December 15, 2022
and 4 more in the library