Ketamine Therapy in Complex Cases: A Cautionary Tale of Exacerbated Personality Traits and the Crucial Role of Comprehensive Follow-Up and Psychosocial Interventions.
Jai Ahuja, Luba Leontieva
Case Reports in Psychiatry 2024 DOI: 10.1155/2024/2143372 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | 75-year-old female with treatment-resistant depression |
| Intervention | Ketamine infusion therapy |
| Topics | Depression Esketamine Ketamine |
| Keywords | Ketamine therapy Geriatric psychiatry Adverse effects Personalized medicine |
| Key findings | Ketamine infusion therapy was associated with an unexpected increase in suicidal ideation in a 75-year-old patient with treatment-resistant depression. |
Abstract
This case report examines the unexpected increase in suicidal ideation following ketamine infusion therapy in a 75-year-old female with a history of treatment-resistant depression. Despite ketamine's established efficacy in treating depression and acute suicidality, this patient's condition deteriorated posttreatment. The report delves into the patient's complex background, including psychosocial stressors, genetic predisposition to depression, and a history of personality traits that may have influenced her response to ketamine. This case underscores the importance of cautious administration of ketamine, especially in patients with personality disorders, and calls for deeper understanding and individualized treatment plans in mental health care. It is a reminder of the complexities involved in treating mental health conditions and the varying effects of treatments like ketamine on different individuals.
Comparable studies
Other case reports and case series on ketamine for depression, most cited first.