Association of Ketamine With Psychiatric Symptoms and Implications for Its Therapeutic Use and for Understanding Schizophrenia
K. Beck, Guy Hindley, Faith Borgan, Cedric E. Ginestet, Robert A. McCutcheon, S. Brugger, Naomi R. Driesen, Mohini Ranganathan, Deepak C. D’Souza, M. Taylor, John H. Krystal, Oliver Howes
JAMA Network Open May 1, 2020 DOI: 10.1001/jamanetworkopen.2020.4693 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Meta-analysis Peer reviewed |
|---|---|
| Population | Healthy volunteers and patients with schizophrenia |
| Intervention | Ketamine |
| Topics | Esketamine Ketamine |
| Citations | 179 |
| Key findings | Ketamine produces transient psychopathological effects that differ between healthy volunteers and patients with schizophrenia, influenced by experimental factors such as dose and administration route. |
Abstract
This meta-analysis assesses the psychopathological outcomes in healthy volunteers and patients with schizophrenia treated with ketamine and the experimental factors associated with these findings.
Comparable studies
Other systematic reviews and meta-analyses on ketamine, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| The effect of a single dose of intravenous ketamine on suicidal ideation: a systematic review and individual participant data meta-analysis Depressed patients with suicidal ideation at baseline | 2017 | Systematic review and individual participant data meta-analysis | n = 167 |
| Ketamine use: a review Ketamine users | 2011 | Systematic review | |
| Ketamine and Other NMDA Antagonists: Early Clinical Trials and Possible Mechanisms in Depression Participants with major depression in placebo-controlled, double-blind, randomized... | 2015 | Systematic review and meta-analysis | |
| Ketamine and postoperative pain – a quantitative systematic review of randomised trials Surgical patients from 25 countries | 2004 | Systematic review | n = 2,839 |
| Side-effects associated with ketamine use in depression: a systematic review. Patients with depression | 2018 | Systematic review |
Citations in the library
Cited by 70
- Substance-Induced Psychoses: An Updated Literature Review Frontiers in Psychiatry December 23, 2021
- Ketamine and serotonergic psychedelics: An update on the mechanisms and biosignatures underlying rapid-acting antidepressant treatment Neuropharmacology January 13, 2023
- Bridging the Gap? Altered Thalamocortical Connectivity in Psychotic and Psychedelic States Frontiers in Psychiatry October 13, 2021
- Candidate Strategies for Development of a Rapid-Acting Antidepressant Class That Does Not Result in Neuropsychiatric Adverse Effects: Prevention of Ketamine-Induced Neuropsychiatric Adverse Reactions International Journal of Molecular Sciences October 26, 2020
- Ketamine for psychotic depression: An overview of the glutamatergic system and ketamine's mechanisms associated with antidepressant and psychotomimetic effects. Psychiatry Research October 1, 2021
and 65 more in the library
Cites 25
- A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression Archives of General Psychiatry August 1, 2006
- Subanesthetic Effects of the Noncompetitive NMDA Antagonist, Ketamine, in Humans Archives of General Psychiatry March 1, 1994
- Efficacy and Safety of Intranasal Esketamine Adjunctive to Oral Antidepressant Therapy in Treatment-Resistant Depression JAMA Psychiatry December 27, 2017
- Ketamine-Induced Deficits in Auditory and Visual Context-Dependent Processing in Healthy Volunteers Archives of General Psychiatry December 1, 2000
- Ketamine activates psychosis and alters limbic blood flow in schizophrenia Neuroreport April 1, 1995
and 20 more in the library