Restructuring reward processing with Mindfulness-Oriented Recovery Enhancement: novel therapeutic mechanisms to remediate hedonic dysregulation in addiction, stress, and pain.
Annals of the New York Academy of Sciences April 1, 2016 DOI: 10.1111/nyas.13034 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Theoretical or philosophical paper Peer reviewed |
|---|---|
| Intervention | Mindfulness-Oriented Recovery Enhancement (MORE) |
| Topics | Addiction Meditation |
| Citations | 136 |
| Key points | Argues that Mindfulness-Oriented Recovery Enhancement (MORE), which combines mindfulness meditation with reappraisal and savoring, targets the shift in salience from natural rewards to drug rewards that underlies addiction. Clinical and biobehavioral data from several completed and ongoing trials suggest MORE may exert beneficial effects on addictive behaviors and their neurobiological underpinnings, but the authors state that additional studies are needed. |
Abstract
Though valuation processes are fundamental to survival of the human species, hedonic dysregulation is at the root of an array of maladies, including addiction, stress, and chronic pain, as evidenced by the allostatic shift in the relative salience of natural reward to drug reward observed among persons with severe substance use disorders. To address this crucial problem, novel interventions are needed to restore hedonic regulatory processes gone awry in persons exhibiting addictive behaviors. This article describes a theoretical rationale and empirical evidence for the effects of one such new intervention, Mindfulness-Oriented Recovery Enhancement (MORE), on top-down and bottom-up mechanisms implicated in cognitive control and hedonic regulation. MORE is innovative and distinct from extant mindfulness-based interventions in that it unites traditional mindfulness meditation with reappraisal and savoring strategies designed to reverse the downward shift in salience of natural reward relative to drug reward, representing a crucial tipping point to disrupt the progression of addiction-a mechanistic target that no other behavioral intervention has been designed to address. Though additional studies are needed, clinical and biobehavioral data from several completed and ongoing trials suggest that MORE may exert salutary effects on addictive behaviors and the neurobiological processes that underpin them.
Comparable studies
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|---|---|---|---|
| Psychedelics as Medicines: An Emerging New Paradigm General population | 2016 | Theoretical or philosophical paper | |
| Ayahuasca’s entwined efficacy: An ethnographic study of ritual healing from ‘addiction’ | 2017 | Theoretical or philosophical paper | |
| Hypotheses Regarding the Mechanisms of Ayahuasca in the Treatment of Addictions | 2012 | Theoretical or philosophical paper | |
| Biosynthesis of an Anti-Addiction Agent from the Iboga Plant. | 2019 | Theoretical or philosophical paper | |
| Why MDMA therapy for alcohol use disorder? And why now? | 2018 | Theoretical or philosophical paper |
Citations in the library
Cited by 44
- Testing the mindfulness-to-meaning theory: Evidence for mindful positive emotion regulation from a reanalysis of longitudinal data. PLoS One December 6, 2017
- Positive Psychological States in the Arc from Mindfulness to Self-Transcendence: Extensions of the Mindfulness-to-Meaning Theory and Applications to Addiction and Chronic Pain Treatment Current Opinion in Psychology January 14, 2019
- Restructuring Reward Mechanisms in Nicotine Addiction: A Pilot fMRI Study of Mindfulness‐Oriented Recovery Enhancement for Cigarette Smokers Evidence-based Complementary and Alternative Medicine 2017
- Pain, hedonic regulation, and opioid misuse: Modulation of momentary experience by Mindfulness-Oriented Recovery Enhancement in opioid-treated chronic pain patients Drug and Alcohol Dependence March 29, 2017
- Endogenous theta stimulation during meditation predicts reduced opioid dosing following treatment with Mindfulness-Oriented Recovery Enhancement. Neuropsychopharmacology September 12, 2020
and 39 more in the library
Cites 13
- The Tree of Knowledge: The Biological Roots of Human Understanding Complicity An International Journal of Complexity and Education July 1, 2007
- Self-awareness, self-regulation, and self-transcendence (S-ART): a framework for understanding the neurobiological mechanisms of mindfulness Frontiers in Human Neuroscience 2012
- Attending to the present: mindfulness meditation reveals distinct neural modes of self-reference Social Cognitive and Affective Neuroscience August 13, 2007
- The Mindfulness-to-Meaning Theory: Extensions, Applications, and Challenges at the Attention–Appraisal–Emotion Interface Psychological Inquiry October 2, 2015
- Restructuring Reward Mechanisms in Nicotine Addiction: A Pilot fMRI Study of Mindfulness‐Oriented Recovery Enhancement for Cigarette Smokers Evidence-based Complementary and Alternative Medicine 2017
and 8 more in the library