Ketamine Therapy in Patients of Alcohol Use Disorder: A Prospective Pilot Study to Evaluate Abstinence Rate with This Add-on Treatment Modality
Nidhi Purushottum Marvania, Anto Leroy Rayan, Dhruti Vijaykumar Merchant, Drashti Paragkumar Shah, Prakash Ishwarlal Mehta, Fenil Dineshkumar Modh
Annals of Indian Psychiatry September 3, 2024 DOI: 10.4103/aip.aip_110_24 (opens in new tab) via DOAJ
Summary
AI-generated from the abstractThree doses of intravenous ketamine, given after detoxification, significantly increased confidence to abstain from alcohol in people with alcohol use disorder. Confidence scores rose 51.98% from baseline after the sessions, though the effect may diminish over time, indicating a need for ongoing support.
Study at a glance
| Characteristics | Pre-post intervention study Pilot study Peer reviewed |
|---|---|
| Sample size | 18 |
| Population | Individuals with alcohol use disorder |
| Intervention | Ketamine |
| Duration | Three doses with a 3-day gap between each; final assessment after three sessions |
| Topics | Addiction |
| Keywords | Abstinence and craving Ketamine therapy Paired t-test |
| Citations | 3 |
| Key finding | Ketamine therapy significantly increased confidence to abstain from alcohol, with a 51.98% increase in mean scores from baseline. |
Abstract
Background: Alcohol use disorders (AUDs) are emerging as a substance use disorder having various psychological and physical ill effects leading to hampering of individual’s productivity and functioning. Aims: The aim of this study was to evaluate the efficacy of ketamine in enhancing confidence levels to abstain from alcohol. Methods: Eighteen patients were administered ketamine intravenously after detoxification; a total of three doses, with a 3-day gap between each. The Alcohol Abstinence Self-Efficacy Scale was used to measure their confidence in abstaining from alcohol. Results: The study revealed a significant increase in mean confidence scores after three ketamine sessions, with a final assessment showing a 51.98% increase in confidence from baseline. Conclusions: The study found that ketamine therapy significantly increased confidence levels in individuals with AUD to abstain from alcohol, with P = 0.05 threshold. However, the impact may wane over time, suggesting the need for additional support or maintenance treatments.