Differences in how NMDA antagonists modulate negative affective biases in male rats may serve as a predictor of clinical efficacy in major depressive disorder.
Justyna K. Hinchcliffe, Katie Kamenish, Julia M. Bartlett, Roberto Arban, Bastian Hengerer, Emma Robinson
Transl Psychiatry May 29, 2026 DOI: 10.1038/s41398-026-04133-z (opens in new tab) via PubMed
Summary
AI-generated from the abstractThe way NMDA antagonists alter negative affective biases in male rats could predict how well these drugs will work in humans with major depressive disorder.
Study at a glance
| Characteristics | Preclinical study Peer reviewed |
|---|---|
| Population | Male rats |
| Intervention | NMDA antagonists |
| Key finding | Differences in how NMDA antagonists modulate negative affective biases in male rats may predict clinical efficacy in major depressive disorder. |
Abstract
Differences in how NMDA antagonists modulate negative affective biases in male rats may serve as a predictor of clinical efficacy in major depressive disorder.