Structural Neurotoxic and Neuroprotective Effects of Ketamine and Esketamine in Preclinical and Human Studies: A Systematic Review
Tychique T. Wasolua, Tanner J. Bommersbach, Roger S McIntyre, Taeho Greg Rhee
Research Square May 27, 2026 preprint DOI: 10.21203/rs.3.rs-9827580/v1 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Systematic review |
|---|---|
| Population | Preclinical and human |
| Topics | Esketamine Ketamine |
| Key findings | Ketamine and esketamine have both neurotoxic and neuroprotective effects, with outcomes dependent on dose and experimental conditions. |
Abstract
Structural Neurotoxic and Neuroprotective Effects of Ketamine and Esketamine in Preclinical and Human Studies: A Systematic Review