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Behavioral pharmacology of mescaline - the role of serotonin 5-HT2A, 5-HT2B, 5-HT2C and 5-HT1A receptors

Lucie Olejníková-Ladislavová, Michaela Fujáková-Lipski, Klára Šíchová, Hynek Danda, Kateřina Syrová, Jiří Horáček, Tomáš Páleníček

bioRxiv Preprint Server August 28, 2024 preprint DOI: 10.1101/2024.08.28.610032 (opens in new tab)

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AI-extracted from the abstract
Characteristics Review
Topics Mescaline Serotonin
Key findings The precise role of different serotonin receptor subtypes in mescaline's behavioral pharmacology is not fully understood.

Abstract

Rationale Mescaline is a classical psychedelic compound with a phenylethylamine structure that primarily acts on serotonin 5-HT2A/C receptors, but also binds to 5-HT1A and 5-HT2B receptors. Despite being the first psychedelic ever isolated and synthesized, the precise role of different serotonin receptor subtypes in its behavioral pharmacology is not fully understood.

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