Synthesis and Biological Evaluation of 4-Bromo- N,N- dimethyltryptamine (4-Br-DMT): A Synthetic Building Block for Future Analog Development
Elena Bray, Grant C. Glatfelter, Alexander D. Maitland, Nicholas R. Gonzalez, Donna Walther, Jeanine Yacoub, Michael H. Baumann, Jacqueline L von Salm
ACS Omega June 23, 2026 DOI: 10.1021/acsomega.6c02996 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Preclinical study Peer reviewed |
|---|---|
| Population | Mice |
| Intervention | 4-Br-DMT |
| Topics | 5-MeO-DMT DMT |
| Keywords | Chemical synthesis Component thermodynamics Property philosophy Key lock Combinatorial chemistry |
| Key points | 4-Br-DMT has a serotonergic profile without psychedelic-like effects in mice but has a reduced safety profile compared to psilocin and DMT. |
Abstract
-dimethyltryptamine (DMT). Overall, the data indicate that 4-Br-DMT has a serotonergic profile without psychedelic-like effects in mice but has a reduced safety profile compared to psilocin and DMT.