Understanding the effects of lysergic acid diethylamide and the importance of its prevention
Burak Okumuş, Ahmet Metin, İ. Afşin Kariper
Health Sciences Review August 12, 2023 DOI: 10.1016/j.hsr.2023.100107 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | LSD |
| Keywords | Pharmacokinetic effects Physicochemical properties Psychiatric effects Receptor effect mechanism |
| Citations | 4 |
| Key findings | LSD is used for treating psychiatric disorders such as depression, post-traumatic stress disorder, and addiction. |
Abstract
This review is on lysergic acid diethylamide (LSD), which has a halogenic effect and is addictive. Up to now, LSD has been used for pleasure-inducing or spiritual purposes. Since it is soluble in water, it can be administered in different forms. The final decision about whether it is addictive or not is undecided. The use of LSD is extensive and is also used for treating psychiatric disorders such as depression, post-traumatic stress disorder, and addiction. In this review, firstly, general information on LSD was explained. Then, its physicochemical properties (solubility, melting point, stability), pharmacokinetics, receptor interactions, mechanism of action, studies with healthy subjects (subjective effects, autonomic and endocrine effects, psychiatric effects), and preventive studies against addiction effects were discussed. Finally, there are recommendations for the use of LSD.
Comparable studies
Other narrative reviews on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Study of a New Schizophrenomimetic Drug—Sernyl | 1959 | Review | |
| Classic psychedelics: An integrative review of epidemiology, therapeutics, mystical experience, and brain network function. General population | 2019 | Integrative review | |
| The Pharmacology of Lysergic Acid Diethylamide: A Review | 2008 | Review | |
| Serotonin research: contributions to understanding psychoses | 2008 | Review | |
| ADVERSE REACTIONS TO PSYCHEDELIC DRUGS. A REVIEW OF THE LITERATURE | 1984 | Review |
Citations in the library
Cited by 2
- Tripping into the unknown: Exploring the experiences of first-time LSD users through global drug survey insights. Journal of Psychopharmacology August 1, 2024
- From Venerable Cultural Practices to Modern Psychological Solutions: Enter Entheogens into Mainstream Medicine European Journal of Arts Humanities and Social Sciences May 1, 2024
Cites 39
- Human hallucinogen research: guidelines for safety. Journal of Psychopharmacology July 1, 2008
- Psychedelics Promote Structural and Functional Neural Plasticity Cell Reports June 1, 2018
- Safety and Efficacy of Lysergic Acid Diethylamide-Assisted Psychotherapy for Anxiety Associated With Life-threatening Diseases The Journal of Nervous and Mental Disease March 4, 2014
- Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms. Scientific Reports October 13, 2017
- The Pharmacology of Lysergic Acid Diethylamide: A Review CNS Neuroscience & Therapeutics November 11, 2008
and 34 more in the library