The Differentiation of Lysergic Acid Diethylamide (LSD) from N-Methyl-N-Propyl and N-Butyl Amides of Lysergic Acid
Journal of Forensic Sciences May 1, 1989 DOI: 10.1520/jfs12674j (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Topics | LSD |
| Citations | 12 |
| Key findings | EI/MS combined with other analytical techniques can differentiate LSD from the six synthetic amide variants tested. |
Abstract
Abstract The N-methyl-N-propyl, N-methyl-N-isopropy, N-butyl, N-isobutyl, N-sec-butyl and N-tert-butyl amides of lysergic acid were synthesized to determine the specificity of electron impact mass spectroscopy (EI/MS), when combined with other analytical techniques, for the identification of lysergic acid diethylamide (LSD). After separation of the C8 axial and equatorial isomers by preparative thin-layer chromatography, the amides were subjected to gas-liquid chromatography (GLC), thin-layer chromatography (TLC), high pressure liquid chromatography (HPLC), and EI/MS. EI/MS, when combined with other analytical techniques, is shown to be capable of differentiating LSD from any of the other compounds included in this study.
Comparable studies
Other experimental studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Neural correlates of the LSD experience revealed by multimodal neuroimaging. Human participants | 2016 | Experimental study | |
| Crystal structure of an LSD-bound human serotonin receptor | 2017 | Experimental study with structural biology and molecular dynamics simulations | |
| Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe Midbrain neurons containing serotonin | 1968 | Experimental study | |
| Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD. Human brain | 2017 | Experimental study | |
| LSD-Assisted Psychotherapy in Patients with Terminal Cancer Cancer patients | 1973 | Experimental study | n = 60 |
Citations in the library
Cited by 6
- Return of the lysergamides. Part I: Analytical and behavioural characterization of 1‐propionyl‐d‐lysergic acid diethylamide (1P‐LSD) Drug Testing and Analysis October 12, 2015
- Return of the lysergamides. Part V: Analytical and behavioural characterization of 1‐butanoyl‐d‐lysergic acid diethylamide (1B‐LSD) Drug Testing and Analysis May 13, 2019
- Return of the lysergamides. Part VI: Analytical and behavioural characterization of 1‐cyclopropanoyl‐d‐lysergic acid diethylamide (1CP‐LSD) Drug Testing and Analysis March 16, 2020
- Separating the wheat from the chaff: Observations on the analysis of lysergamides LSD, MIPLA, and LAMPA Drug Testing and Analysis May 22, 2021
- Synthesis and analytical characterization of 1-(2-thienoyl)-6-allyl-nor-d-lysergic acid diethylamide (1T-AL-LAD). Drug Testing and Analysis April 1, 2025
and 1 more in the library