Computational design of an improved photoswitchable psychedelic based on light absorption, membrane permeation and protein binding.
Vito F. Palmisano, Claudio Agnorelli, Shirin Faraji, Juan J. Nogueira
Physical chemistry chemical physics : PCCP September 18, 2025 DOI: 10.1039/d5cp01252j (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Computational study Peer reviewed |
|---|---|
| Key points | The photoswitch PQ-azo-N,N-DMT (34) shows improved features over azo-N,N-DMT (1), including tight binding to 5-HT2AR, retention of LSD-like interactions, positive membrane permeability, and strong red-shifted absorption for visible-light photocontrol. |
Abstract
Psychedelic compounds can induce rapid-acting and long-lasting antidepressant benefits. Understanding the role of their hallucinatory effects is crucial for shaping the future trajectory of antidepressant drug development. Photoswitchable compounds targeting the 5-HT2AR offer precise spatio-temporal control over the activation of different downstream pathways. In this work, we computationally discovered PQ-azo-N,N-DMT (34), a photoswitch with improved features compared to the previously synthesized azo-N,N-DMT (1). The new compound shows tight binding to the 5-HT2AR, retaining all important interactions of lysergic acid diethylamide (LSD), exhibits positive membrane permeability, and has a strong red-shifted absorption that would allow photocontrol in the visible spectrum.