LSD
G. Wayne Craig, George B. Kauffman
The Chemical Educator December 1, 2006 DOI: 10.1333/s00897061090a (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | LSD |
| Key findings | LSD's incredible potency challenged the lock-and-key model of enzyme-substrate recognition. |
Abstract
Albert Hofmann’s discovery of LSD by “chance or by a higher plan” led to a revolution in the pharmaceutical industry, inspiring research to understand how a chemical’s structure is recognized and how this recognition triggers a physiological response. The incredible potency of this drug challenged the conventional lock-and-key model that Emil Fischer had proposed for enzymes. In fact, the astounding physiological properties of LSD may have overshadowed the scientific expertise and outstanding qualities of its discoverer, Albert Hofmann, who celebrated his 100th birthday this year. The first article in this series (pp 413-420) sketches Hofmann’s discovery of LSD, its use as an adjunct to meditation, creativity, and consciousness expansion, and treatment of the mentally ill as well as its abuse as a pleasure drug. The third article (pp 427-436) discusses Hofmann’s life and especially his chemistry and his passion for nature. We are also reviewing a Festschrift commemorating his centenary (pp 451-452).