Apical regional wall motion abnormalities reminiscent to Tako-Tsubo cardiomyopathy following consumption of psychoactive fungi.
Holger M Nef, Helge Möllmann, Pirmin Hilpert, Nicola Krause, Christian Troidl, Michael Weber, Andreas Rolf, Thorsten Dill, Christian Hamm, A Elsässer
International journal of cardiology May 1, 2009 DOI: 10.1016/j.ijcard.2007.12.064 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | Young male patient |
| Duration | Several days |
| Citations | 24 |
| Key findings | Consumption of psychoactive fungi can trigger a reversible contractile dysfunction resembling Tako-Tsubo cardiomyopathy in the absence of coronary artery disease. |
Abstract
Consumption of natural hallucinogenic substances continues to be a problem. In this case we report from a young male patient presenting with an acute coronary syndrome with significant ST-elevation after the abuse of psychoactive fungi, commonly referred to as "magic mushrooms". Coronary angiography excludes relevant coronary artery disease. In ventriculography contractile dysfunction with hypokinesia in the apical segments could be documented reminiscent to wall motion abnormalities in Tako-Tsubo cardiomyopathy (TTC). Cardiovascular magnetic resonance imaging showed no pathological signal activity in the late-enhancement sequences ruling out myocardial infarction or inflammatory processes. Ventricular function normalized within several days. The active metabolite of psychoactive fungi psilocybin is known to interact with several different dopaminergic, adrenergic and serotonergic receptors. Thus, the pathomechanisms leading to contractile dysfunction after consumption of psychoactive fungi are reminiscent to those documented in TTC.