DOES THE PHENOMENOLOGY OF THE PSILOCYBIN EXPERIENCE PREDICT LONG-TERM EFFECTS ON MOOD AND WELL-BEING IN HEALTHY VOLUNTEERS?
Tomáš Páleníček, Tereza Klučková, Marek Nikolič, Čestmír Vejmola, Filip Tylš, Vojtěch Viktorin, Jiří Horáček, Martin Brunovský
IBRO Neuroscience Reports November 6, 2023 DOI: 10.1016/j.ibneur.2023.08.1240 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Population | Healthy volunteers |
| Intervention | Psilocybin |
| Topics | Philosophy of mind Psilocybin |
| Key findings | Positive phenomenology during psilocybin experiences was associated with positive long-term outcomes, while fearful phenomenology was associated with negative long-term outcomes. |
Abstract
INTRODUCTION: The mechanisms by which the psychedelic drug psilocybin, a novel rapid-acting antidepressant, improves depressive symptoms are still unclear. One candidate mechanism is the impact of the phenomenology of the psychedelic experience, with positive phenomenology hypothesised to be associated with positive long-term outcomes and fearful phenomenology hypothesised to be associated with negative long-term outcomes. The present study investigated how phenomenology influences long-term effects on mood, spirituality, and relationships with self, life, and others following single and repeated experiences in healthy volunteers.
Comparable studies
Other observational and cohort studies on psilocybin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms. Patients with treatment-resistant depression | 2017 | Observational cohort | n = 19 |
| Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels Healthy volunteers | 2019 | Observational cohort | n = 8 |
| Increased spontaneous MEG signal diversity for psychoactive doses of ketamine, LSD and psilocybin Humans | 2017 | Observational study | |
| Classic psychedelic use is associated with reduced psychological distress and suicidality in the United States adult population. USA adult respondents from the National Survey on Drug Use and Health (2008-2012) | 2015 | Observational cohort | n = 190,000 |
| Prediction of Psilocybin Response in Healthy Volunteers Healthy volunteers | 2012 | Observational cohort | n = 409 |