Ibogaine: A Novel Anti-Addictive Compound A Comprehensive Literature Review
Maryland Shared Open Access Repository 2003 DOI: 10.13016/m2txg0-wv9p (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Peer reviewed |
|---|---|
| Topics | Ibogaine |
| Keywords | Indole alkaloid Chemical constituents Indole test Natural compound Traditional medicine Alkaloids |
| Key points | Ibogaine is a naturally occurring indole alkaloid from Tabernathe iboga, chemically a tryptamine, first extracted in 1901, and can be synthesized from nicotinamide. |
Abstract
Ibogaine is a naturally occurring indole alkaloid, found in a variety of African shrubsof the Tabernathe genus (Obach, Pablo, and Mash, 1998). The root of the Tabernathe ibogaplant (also known as eboga) is the most frequently cited source of ibogaine, and this plantcontains 11 other known psychoactive constituents (Popik, and Skolnick, 1999). Chemically,ibogaine is classified as a tryptamine, being a rigid analogue of melatonin, and is structurallysimilar to harmaline, another natural alkaloid and psychedelic (Xu et al, 2000). Ibogaine wasfirst extracted from the Tabernathe iboga root in 1901 by Dybowsky and Landrin (Goutarel,Gollnhofer, and Sillans, 1993). It can also be synthesised from nicotinamide by way of a 13or 14 step process, although extraction from the iboga root is a simpler method for obtainingthe compound (Shulgin and Shulgin, 1977).