Letter to the editor: Comments on ‘Striking long-term beneficial effects of single-dose psilocybin and psychedelic mushroom extract in the SAPAP3 rodent model of OCD-like excessive self-grooming’ by Brownstien et al. (2024)
James J Gattuso, Carey Wilson, Anthony J. Hannan, Thibault Renoir
Molecular Psychiatry April 6, 2025 DOI: 10.1038/s41380-025-03005-0 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Preclinical study Peer reviewed |
|---|---|
| Population | SAPAP3 knockout (KO) mouse model of obsessive-compulsive disorder (OCD)-like behaviours |
| Intervention | psychedelic mushroom extract |
| Topics | Psilocybin |
| Citations | 2 |
| Key points | Psychedelic mushroom extract (PME) showed potential therapeutic benefits in reducing OCD-like behaviors in SAPAP3 knockout mice. |
Abstract
The growing interest in psychedelic compounds for psychiatric disorders highlights the importance of well-designed preclinical studies [ 1 , 2 ]. In this context, Brownstein et al. [ 3 ] recently reported evidence of potential therapeutic benefits of psychedelic mushroom extract (PME) in the SAPAP3 knockout (KO) mouse model of obsessive-compulsive disorder (OCD)-like behaviours.
Comparable studies
Other preclinical and animal studies on psilocybin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo Mice | 2021 | Observational cohort | |
| Harnessing psilocybin: antidepressant-like behavioral and synaptic actions of psilocybin are independent of 5-HT2R activation in mice Mice | 2021 | Experimental study | |
| Psychedelics reopen the social reward learning critical period Mice | 2023 | Experimental study in mice | |
| Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species. C57BL/6J mice | 2020 | Experimental study with dose-response experiments | |
| Effects of psilocybin on hippocampal neurogenesis and extinction of trace fear conditioning Mice | 2013 | Experimental study |
Citations in the library
Cites 16
- Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo Neuron July 5, 2021
- Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Study of Depression ACS Chemical Neuroscience March 5, 2020
- Sex differences and serotonergic mechanisms in the behavioural effects of psilocin Behavioural Pharmacology October 13, 2015
- Effects ofPsilocybe argentipeson Marble-Burying Behavior in Mice Bioscience Biotechnology and Biochemistry August 23, 2009
- Psilocybin and LSD have no long-lasting effects in an animal model of alcohol relapse Neuropsychopharmacology May 5, 2020
and 11 more in the library