Sleep deprivation reduces default mode network connectivity and anti-correlation during rest and task performance
Jack A. De Havas, Sarayu Parimal, Chun Siong Soon, Michael W.L. Chee
Neuroimage August 19, 2011 DOI: 10.1016/j.neuroimage.2011.08.026 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Sample size | 26 |
| Population | Healthy participants |
| Intervention | Sleep deprivation |
| Duration | Approximately 24h of total sleep deprivation |
| Topics | Default mode network |
| Citations | 371 |
| Key findings | Sleep deprivation reduces functional connectivity within the Default Mode Network and its anti-correlation with the anti-correlated network, both at rest and during a visual attention task. |
Abstract
Sleep deprivation (SD) can alter extrinsic, task-related fMRI signal involved in attention, memory and executive function. However, its effects on intrinsic low-frequency connectivity within the Default Mode Network (DMN) and its related anti-correlated network (ACN) have not been well characterized. We investigated the effect of SD on functional connectivity within the DMN, and on DMN-ACN anti-correlation, both during the resting state and during performance of a visual attention task (VAT). 26 healthy participants underwent fMRI twice: once after a normal night of sleep in rested wakefulness (RW) and once following approximately 24h of total SD. A seed-based approach was used to examine pairwise correlations of low-frequency fMRI signal across different nodes in each state. SD was associated with significant selective reductions in DMN functional connectivity and DMN-ACN anti-correlation. This was congruent across resting state and VAT analyses, suggesting that SD induces a robust alteration in the intrinsic connectivity within and between these networks.
Comparable studies
Other observational and cohort studies on default mode network, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| A default mode of brain function Normal adult human brain | 2001 | Observational study | |
| Resting-State Functional Connectivity Reflects Structural Connectivity in the Default Mode Network Healthy subjects | 2008 | Observational cohort | |
| Meditation experience is associated with increased cortical thickness Participants with extensive Insight meditation experience and matched controls | 2005 | Observational cohort | n = 20 |
| Meditation experience is associated with differences in default mode network activity and connectivity Experienced meditators and matched meditation-naive controls | 2011 | Observational cohort | |
| The precuneus/posterior cingulate cortex plays a pivotal role in the default mode network: Evidence from a partial correlation network analysis Healthy subjects | 2008 | Observational study |
Citations in the library
Cited by 25
- Reduced functional segregation between the default mode network and the executive control network in healthy older adults: A longitudinal study Neuroimage March 19, 2016
- Taking the body off the mind: Decreased functional connectivity between somatomotor and default‐mode networks following Floatation‐REST Human Brain Mapping April 9, 2021
- Neuronal oscillations and synchronicity associated with gamma-hydroxybutyrate during resting-state in healthy male volunteers Psychopharmacology July 1, 2017
- ‘Wearing down of the self’: Embodiment, writing and disruptions of identity in transformational festival fieldwork Methodological Innovations 2017
- Infraslow Dynamic Patterns in Human Cortical Networks Track a Spectrum of External to Internal Attention. Human Brain Mapping February 15, 2025
and 20 more in the library
Cites 7
- A default mode of brain function Proceedings of the National Academy of Sciences January 16, 2001
- Decoupling of the brain's default mode network during deep sleep Proceedings of the National Academy of Sciences June 19, 2009
- Breakdown of within- and between-network Resting State Functional Magnetic Resonance Imaging Connectivity during Propofol-induced Loss of Consciousness Anesthesiology September 30, 2010
- Investigating the Functional Heterogeneity of the Default Mode Network Using Coordinate-Based Meta-Analytic Modeling Journal of Neuroscience November 18, 2009
- Development of the Brain's Default Mode Network from Wakefulness to Slow Wave Sleep Cerebral Cortex February 17, 2011
and 2 more in the library