Ibogaine: Revisiting an Ancient Alkaloid for Modern Opioid Dependence
Markus D Moore, Andrew Moore, Saeed K Alzghari
Substance Use & Misuse December 17, 2025 DOI: 10.1080/10826084.2025.2604213 (opens in new tab)
Study at a glance
AI-extracted from the abstractAbstract
Ibogaine is an interesting candidate that needs further study to determine its safety and potential for treating opioid dependence.
Comparable studies
Other narrative reviews on ibogaine for addiction, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| The Anti-Addiction Drug Ibogaine and the Heart: A Delicate Relation Humans, animals | 2015 | Review | |
| Ibogaine in the treatment of substance dependence. | 2013 | Review | |
| Ibogaine, an anti-addictive drug: pharmacology and time to go further in development. A narrative review. | 2008 | Review | |
| A review of chemical agents in the pharmacotherapy of addiction. | 2002 | Review | |
| Engineering Safer Psychedelics for Treating Addiction. | 2021 | Review |
Citations in the library
Cites 11
- The ibogaine medical subculture. Journal of Ethnopharmacology January 4, 2008
- Magnesium-ibogaine therapy in veterans with traumatic brain injuries. Nature Medicine February 1, 2024
- Subjective effectiveness of ibogaine treatment for problematic opioid consumption: Short- and long-term outcomes and current psychological functioning. Journal of Psychedelic Studies November 1, 2017
- Safety of ibogaine administration in detoxification of opioid-dependent individuals: a descriptive open-label observational study. Addiction 2022
- Noribogaine, but not 18-MC, exhibits similar actions as ibogaine on GDNF expression and ethanol self-administration. Addiction Biology October 1, 2010
and 6 more in the library