Study of the Biology, Medicinal and Therapeutic Properties of Amanita muscaria (L) Lam. (Basidiomycota: Agaricales: Amanitaceae)
Marco Vinícios de Oliveira Santana, Carlos Henrique Marchiori, Klebert de Paula Malheiros
Middle East Research Journal of Medical Sciences January 2, 2026 DOI: 10.36348/merjms.2026.v06i01.001 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Keywords | Amanita Ibotenic acid Limiting Traditional medicine Pharmacology |
| Key findings | Amanita muscaria contains bioactive compounds with potential therapeutic applications for neurodegenerative conditions, but toxicity remains a limiting factor. |
Abstract
Amanita muscaria (L.) Lam, 1783 (Agaricales: Amanitaceae), commonly known as the fly agaric, is one of the most iconic and visually distinctive mushroom species, recognized for its striking red cap with white spots. This species has significant biological, ecological, medicinal, and ethnomycological relevance. Its bioactive compounds, mainly muscimol, ibotenic acid, and muscarine, exhibit notable psychoactive, neuroactive, and therapeutic properties. Recent studies have highlighted its potential role in neurodegenerative conditions such as Parkinson’s disease, Alzheimer’s disease, epilepsy, and depression, due to its interaction with GABAergic and glutamatergic neurotransmission. Additionally, its ethnobotanical use in traditional healing practices, spiritual ceremonies, and as an insecticidal agent further emphasizes its relevance. However, toxicity remains a limiting factor regarding its clinical application, demanding careful assessment of dosage, preparation method, and administration routes. Despite these limitations, laboratory findings suggest possible anti-inflammatory, neuroprotective, hepatoprotective, and antioxidant properties, making it a promising candidate for future pharmacological research. This review discusses the biology, morphology, distribution, toxicology, medicinal potential, and therapeutic applications of A. muscaria, providing a comprehensive look into its scientific significance.Abstract: Amanita muscaria (L.) Lam, 1783 (Agaricales: Amanitaceae), commonly known as the fly agaric, is one of the most iconic and visually distinctive mushroom species, recognized for its striking red cap with white spots. This species has significant biological, ecological, medicinal, and ethnomycological relevance. Its bioactive compounds, mainly muscimol, ibotenic acid, and muscarine, exhibit notable psychoactive, neuroactive, and therapeutic properties. Recent studies have highlighted its potential role in neurodegenerative conditions such as Parkinson’s disease, Alzheimer’s disease, epilepsy, and depression, due to its interaction with GABAergic and glutamatergic neurotransmission. Additionally, its ethnobotanical use in traditional healing practices, spiritual ceremonies, and as an insecticidal agent further emphasizes its relevance. However, toxicity remains a limiting factor regarding its clinical application, demanding careful assessment of dosage, preparation method, and administration routes. Despite these limitations, laboratory findings suggest possible anti-inflammatory, neuroprotective, hepatoprotective, and antioxidant properties, making it a promising candidate for future pharmacological research. This review discusses the biology, morphology, distribution, toxicology, medicinal potential, and therapeutic applications of A. muscaria, providing a comprehensive look into its scientific significance.