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Intact neurophysiological markers of death denial in long-term ayahuasca users

Yair Dor-Ziderman, Jonathan David, Aviva Berkovich-Ohana

Psychopharmacology November 10, 2025 DOI: 10.1007/s00213-025-06963-z (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Preliminary study Peer reviewed
Intervention Ayahuasca
Topics Ayahuasca
Keywords Unconscious mind Cognition Denial Hallucinogen Perception Neurophysiology Psychotherapist Clinical psychology
Key points Ayahuasca alters conceptual and affective processing of death but does not affect automatic perceptual unconscious death-denial processes.

Abstract

These findings provide preliminary evidence that while ayahuasca may alter how humans interact with the theme of death on conceptual and affective levels of cognitive processing, on automatic, perceptual unconscious levels of self-specific processing, death-denial processes appear to remain intact.

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