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Management of Chemotherapy-Induced Peripheral Neuropathy (CIPN) in Oncologic Patients—A New Promise? Preliminary Results

Ron Batash, Noam Asna, Syed Ahsan Ali, Tatiana Charkovsky, Murad Asali, Sharon Pelles, Moshe Schaffer

Cancers October 15, 2025 DOI: 10.3390/cancers17203321 (opens in new tab)

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Study at a glance

AI-extracted from the abstract
Characteristics Clinical trial Randomized Peer reviewed
Population Patients with chemotherapy-induced peripheral neuropathy
Topics Ketamine
Keywords Amitriptyline Peripheral neuropathy Transdermal Randomized controlled trial Clinical trial Anesthesia Surgery Chemotherapy-related skin toxicity
Citations 2
Key findings A topical combination of amitriptyline and ketamine at new concentrations appears safe and effective for symptomatic relief of CIPN.

Abstract

This is the first clinical evaluation of a topical combination with new concentrations of amitriptyline and ketamine for CIPN. The results suggest this formulation offers a safe and effective option for symptomatic relief. Larger randomized controlled trials and exploration of transdermal delivery systems are warranted to validate these findings and optimize treatment outcomes.

Comparable studies

Other non-randomized and open-label trials on ketamine, most cited first.

Study Year Design Participants
Rapid Resolution of Suicidal Ideation After a Single Infusion of anN-Methyl-D-Aspartate Antagonist in Patients With Treatment-Resistant Major Depressive Disorder Subjects with DSM-IV-diagnosed treatment-resistant major depressive disorder 2010 Open-label trial n = 33
Intravenous arketamine for treatment-resistant depression: open-label pilot study Humans with treatment-resistant depression 2020 Open-label pilot trial n = 7
A Phase 2 Open Label Study of Efficacy, Safety, and Tolerability of SLS-002 (Intranasal Racemic Ketamine) in Adults with MDD at Imminent Risk of Suicide. Hospitalized patients with Major Depressive Disorder and acute suicidal ideation and... 2024 Open label study n = 17
Ketamine Psychedelic Therapy (KPT): A Review of the Results of Ten Years of Research Alcoholic patients 1997 Controlled clinical trial n = 211
Ketamine Safety and Tolerability in Clinical Trials for Treatment-Resistant Depression Participants with DSM-IV-defined major depressive disorder and treatment-resistant... 2014 Pooled analysis of three clinical trials n = 97

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