Appearance of necrotizing sialometaplasia temporarily associated with MDMA consumption
E. Plaza-Matos, J. López-vicente, N. Larrea-Rodríguez, J. Alberdi-Navarro
Journal of Clinical and Experimental Dentistry 2026 DOI: 10.4317/jced.63836 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case study Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | A 24-year-old woman |
| Intervention | symptomatic treatment |
| Topics | MDMA |
| Keywords | Consumption sociology Mouth mucosa Dermatology Pathology |
| Citations | 1 |
| Key findings | MDMA powder licked onto the oral mucosa may be a new aetiological factor for necrotizing sialometaplasia. |
Abstract
We reported the case of a 24-year-old woman presented with necrotizing sialometaplasia associated temporally with 3,4-methylenedioxymethamphetamine (MDMA) use.The patient reported having consumed MDMA powder licked onto the oral mucosa days before the appearance of the lesions.Symptomatic treatment of the presenting lesions was carried out, with a follow-up that demonstrated complete healing of the lesions.The clinical case is presented and possible pathophysiological mechanisms that may justify the relationship between MDMA and necrotizing sialometaplasia are discussed.This report describes the relationship between a new, previously undescribed aetiological factor related to necrotizing sialometaplasia.
Comparable studies
Other case reports and case series on MDMA, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| 'Eve' and 'Ecstasy'. A report of five deaths associated with the use of MDEA and MDMA Individuals whose deaths were associated with MDMA or MDEA use | 1987 | Case series | n = 5 |
| Pathology of deaths associated with "ecstasy" and "eve" misuse. Young white men aged 20 to 25 who died after using ring-substituted amphetamines (MDMA... | 1996 | Case series | n = 7 |
| 'Eve' and 'Ecstasy' Individuals who died after using MDMA or MDEA | 1987 | Case series | n = 5 |
| A Method of Conducting Therapeutic Sessions with MDMA Clients with clear therapeutic purpose, excluding those with serious functional... | 1998 | Case study | n = 2 |
| Diversity of Psychopathology Associated with use of 3,4-Methylenedioxymethamphetamine (‘Ecstasy’) Psychiatric patients presenting between 1990 and 1992 whose symptoms developed in the... | 1994 | Case series | n = 13 |