Appearance of necrotizing sialometaplasia temporarily associated with MDMA consumption
E. Plaza-Matos, J. López-vicente, N. Larrea-Rodríguez, J. Alberdi-Navarro
Journal of Clinical and Experimental Dentistry January 1, 2026 DOI: 10.4317/jced.63836 (opens in new tab) via OpenAlex
Summary
AI-generated from the abstractA 24-year-old woman developed necrotizing sialometaplasia, a benign inflammatory condition of the salivary glands, after licking MDMA powder onto her oral mucosa. The lesions healed completely with symptomatic treatment. This case suggests a previously unreported link between MDMA use and this condition, possibly through vasoconstrictive or other pathophysiological mechanisms.
Study at a glance
| Characteristics | Case study Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | A 24-year-old woman |
| Intervention | symptomatic treatment |
| Topics | MDMA |
| Keywords | Consumption sociology Mouth mucosa Medicine |
| Citations | 1 |
| Key finding | MDMA powder licked onto the oral mucosa may be a new aetiological factor for necrotizing sialometaplasia. |
Abstract
We reported the case of a 24-year-old woman presented with necrotizing sialometaplasia associated temporally with 3,4-methylenedioxymethamphetamine (MDMA) use.The patient reported having consumed MDMA powder licked onto the oral mucosa days before the appearance of the lesions.Symptomatic treatment of the presenting lesions was carried out, with a follow-up that demonstrated complete healing of the lesions.The clinical case is presented and possible pathophysiological mechanisms that may justify the relationship between MDMA and necrotizing sialometaplasia are discussed.This report describes the relationship between a new, previously undescribed aetiological factor related to necrotizing sialometaplasia.