Effect of ketamine/esketamine on postoperative delirium and cognitive dysfunctions: A systematic review and meta-analysis of randomised trials
Qianqian Guo, Xiaoyong Wei, Zhenghua Dong, Tao Wang, 博之 吉留, Na Sun, Changsheng Li
Indian Journal of Anaesthesia November 18, 2025 DOI: 10.4103/ija.ija_770_25 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Meta-analysis Randomized Peer reviewed |
|---|---|
| Topics | Ketamine Esketamine |
| Keywords | Delirium Perioperative Cognition Subgroup analysis Postoperative cognitive dysfunction Medline Anesthesia Clinical trial Intensive care medicine Randomized controlled trial Meta-analysis |
| Key findings | Perioperative (es)ketamine significantly reduces POD risk but not POND, with esketamine excelling in delirium prevention and racemic ketamine showing better cognitive protection. |
Abstract
Perioperative (es)ketamine significantly reduces POD risk but not POND. Subgroup analyses reveal esketamine excels in delirium prevention, while racemic ketamine shows better cognitive protection.
Comparable studies
Other systematic reviews and meta-analyses on esketamine, most cited first.
Citations in the library
Cites 6
- Association of Ketamine With Psychiatric Symptoms and Implications for Its Therapeutic Use and for Understanding Schizophrenia JAMA Network Open May 1, 2020
- Effect of Esketamine on Postoperative Delirium in Patients Undergoing Cardiac Valve Replacement with Cardiopulmonary Bypass: A Randomized Controlled Trial. Anesthesia & Analgesia October 1, 2024
- Effect of Low-Dose Esketamine on Postoperative Delirium in Elderly Patients Undergoing Total Hip or Knee Arthroplasty: A Randomized Controlled Trial. Drug Design, Development and Therapy 2024
- Interleaved Propofol-Ketamine Maintains DBS Physiology and Hemodynamic Stability: A Double-Blind Randomized Controlled Trial. Movement Disorders April 1, 2024
- Ketamine's Role in Neuroinflammation and Neuroprotection Across Neurological and Psychiatric Disorders: A Narrative Review. Pharmaceuticals August 29, 2025
and 1 more in the library