Comparative Efficacy of Psilocybin and MDMA in PTSD Treatment: A Systematic Review of Long-Term Outcomes
Berkeley Scientific Journal November 13, 2025 DOI: 10.5070/bs329265627 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | MDMA Psilocybin PTSD |
| Keywords | Hallucinogen |
| Key findings | The review compares psilocybin and MDMA's effectiveness in treating PTSD. |
Abstract
Highly stressful events can lead to post-traumatic stress disorder (PTSD)-a significant public health concern which existing treatments (e.g., psychotherapy and traditional medications) have shown marginal efficacy for.Psychedelics-alternatively called hallucinogens-are psychoactive substances that cause perception, mood, and cognitive changes.Because they are known for their impact on neuron plasticity and the formation of new connections, researchers are exploring psychedelics' therapeutic potential for PTSD.This review compares psilocybin and MDMA's effectiveness in treating PTSD.