Psychedelics as neuroplasticity enhancers: Mechanisms, therapeutic applications, and translational challenges
Taslim Uddin, Sharmin Akter, Kaustabh Ghosh
Advanced Neurology December 4, 2025 DOI: 10.36922/an025410095 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | Neuroplasticity Serotonin |
| Keywords | Glutamatergic Translation biology Long-term potentiation Affect linguistics Psychopharmacology Fight-or-flight response |
| Key findings | Psychedelics induce neuroplastic changes through serotonergic and glutamatergic systems, which may explain their therapeutic effects in neuropsychiatric disorders when combined with psychotherapy. |
Abstract
Psychedelics are gaining recognition for their effectiveness as modulators of neuroplasticity in the treatment of a range of neuropsychiatric disorders. Psilocybin, lysergic acid diethylamide, N,N-dimethyltryptamine, and ketamine are substances that mainly affect the serotonergic and glutamatergic systems. They induce rapid synaptogenesis, dendritic remodeling, and changes in functional connectivity within crucial brain networks. The therapeutic benefits observed in depression, post-traumatic stress disorder, and substance use disorders—particularly when integrated with psychotherapy—are attributed to these neuroplastic mechanisms. Despite promising findings, challenges remain regarding safety, long-term effects, and the translation of preclinical results into clinical practice. This review discusses the ethical and legal considerations, as well as translational challenges, that must be addressed before psychedelic-assisted therapies can be fully integrated into modern psychiatry. It also outlines the pharmacological basis of psychedelic action, the molecular and cellular mechanisms underlying neuroplasticity, and the clinical potential of these treatments.