DMT as the Prototype of a New Class of Crisis-Linked Endogenous Consciousness Modulators (cECMs)
John Swygert
Zenodo (CERN European Organization for Nuclear Research) November 23, 2025 preprint DOI: 10.5281/zenodo.17694547 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Theoretical or philosophical paper |
|---|---|
| Topics | DMT |
| Keywords | Falsifiability Class philosophy Consciousness Artificial neural network Predictive coding Deep neural networks Cognitive science Artificial intelligence |
| Key points | Proposes that DMT be classified as a "crisis-linked endogenous consciousness modulator" based on six criteria it uniquely satisfies, distinguishing it from classic psychedelics and conventional neuromodulators. |
Abstract
DescriptionThis preprint proposes a new biological classification for N,N-dimethyltryptamine (DMT): crisis-linked endogenous consciousness modulators (cECMs). Using six mechanistically grounded, falsifiable criteria—endogenous neural biosynthesis, deep evolutionary conservation, ultra-rapid pharmacokinetics, multi-receptor promiscuity, crisis-linked release, and induction of information-rich structured internal states—DMT is shown to uniquely satisfy all criteria. 5-MeO-DMT meets five and is designated borderline; classic psychedelics (psilocin, LSD, mescaline) and conventional neuromodulators fail most criteria. The framework is supported by published evidence of mammalian brain biosynthesis, sigma-1 receptor regulation, TAAR signaling, and ischemia-linked surges. Four concrete, testable predictions are presented. The cECM model provides a precise, predictive alternative to the current “classic psychedelic” taxonomy.
Comparable studies
Other theoretical and historical papers on DMT, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| When the Endogenous Hallucinogenic Trace AmineN,N-Dimethyltryptamine Meets the Sigma-1 Receptor | 2009 | Theoretical or philosophical paper | |
| A Model for the Application of Target-Controlled Intravenous Infusion for a Prolonged Immersive DMT Psychedelic Experience. | 2016 | Theoretical or methodological paper | |
| Dimethyltryptamine (DMT): a biochemical Swiss Army knife in neuroinflammation and neuroprotection? | 2016 | Theoretical or philosophical paper | |
| Dimethyltryptamine Experiments with Psychotics | 1958 | Theoretical or philosophical paper | |
| Enlightening the "Spirit Molecule": Photomodulation of the 5-HT2A Receptor by a Light-Controllable N,N-Dimethyltryptamine Derivative. | 2022 | Theoretical or philosophical paper |