Nutmeg as a Narcotic. A Contribution to the Chemistry and Pharmacology of Nutmeg (Myristica fragrans)
Angewandte Chemie International Edition in English June 1, 1971 DOI: 10.1002/anie.197103701 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | Mescaline |
| Keywords | Nutmeg Myristica fragrans Narcotic Traditional medicine Amphetamine Hallucinogen Pharmacology |
| Citations | 37 |
| Key findings | Allylbenzene derivatives in nutmeg, whose metabolites resemble mescaline and amphetamine, are the psychotropic constituents, and their hallucinogenic intensity may be due to simulating LSD-like structural elements. |
Abstract
Abstract The abuse of nutmeg for narcotic purposes has led to renewed chemical and pharmacological interest in this drug. Several allylbenzene derivatives whose biological transformation products have structures resembling mescaline and amphetamine have been identified as psychotropic constituents. It is suggested that the intensity of the hallucinogenic action of these compounds is due to the possibility of simulation of LSD‐like structural elements.
Comparable studies
Other narrative reviews on mescaline, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Study of a New Schizophrenomimetic Drug—Sernyl | 1959 | Review | |
| Hallucinogens and Serotonin 5-HT2A Receptor-Mediated Signaling Pathways | 2017 | Review | |
| Hallucinogens in Mental Health: Preclinical and Clinical Studies on LSD, Psilocybin, MDMA, and Ketamine | 2020 | Review | |
| Legal highs: staying on top of the flood of novel psychoactive substances | 2015 | Review | |
| Psychedelic Drugs in Biomedicine | 2017 | Review |
Citations in the library
Cited by 2
- Hypothetical biosynthetic pathways of pharmaceutically potential hallucinogenic metabolites in Myristicaceae, mechanistic convergence and co-evolutionary trends in plants and humans. Phytochemistry February 1, 2024
- Plants and mushrooms of abuse. Emergency medicine clinics of North America August 1, 1990