An Efficient Ambient Ionization Mass Spectrometric Approach to Detection and Quantification of the Mescaline Content of Commonly Abused Cacti from the Echinopsis Genus
Cameron M. Longo, Rabi A. Musah
Journal of Forensic Sciences July 16, 2019 DOI: 10.1111/1556-4029.14134 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Analytical chemistry methods development Peer reviewed |
|---|---|
| Population | Commercially available Echinopsis spp. cactus tissue |
| Topics | Mescaline |
| Keywords | Dart ion source Cactus Gas chromatography–mass spectrometry Environmental chemistry |
| Citations | 22 |
| Key points | DART-HRMS is a suitable technique for rapid screening and quantification of mescaline in complex plant-derived matrices, with mescaline levels below 2% dry weight in tested Echinopsis species. |
Abstract
Abstract Unregulated cacti from the genus Echinopsis are used recreationally as mescaline‐containing alternatives to the outlawed peyote. Echinopsis ‐derived plant materials appear in a variety of nondescript forms, making rapid assessment of whether they are mescaline‐containing materials or simply innocuous plant‐derived food products, very challenging. Reported here is a DART ‐ HRMS approach for the rapid detection of mescaline in whole plant material and a validated method for the quantification of mescaline in cactus tissue, using mescaline‐ d 9 as the internal standard. Calibration curves exhibited R 2 values of ≥0.995, and the method exhibited a LLOQ and a linear range of 1 ppm and 1–100 ppm, respectively. Application of the method to commercially available Echinopsis spp. yielded results consistent with previous studies performed by GC ‐ and LC ‐ MS , with mescaline levels of <2% dry weight in all cases. Therefore, DART ‐ HRMS is a suitable technique for the rapid screening of mescaline and its subsequent quantification within complex plant‐derived matrices.