The Effects of Acutely Administered 3,4-Methylenedioxymethamphetamine on Spontaneous Brain Function in Healthy Volunteers Measured with Arterial Spin Labeling and Blood Oxygen Level–Dependent Resting State Functional Connectivity
Robin Carhart-Harris, Kevin Murphy, Robert Leech, David Erritzøe, Matthew B. Wall, Bart Ferguson, Luke T. J. Williams, Leor Roseman, Stefan Brugger, Ineke de Meer, Mark Tanner, Robin J. Tyacke, Kim Wolff, Arjun Sethi, Michael Bloomfield, Tom A. Williams, Mark Bolstridge, Lorna Stewart, Celia J. A. Morgan, Rexford D. Newbould, Amanda Feilding, Hv Curran, David Nutt
Biological Psychiatry January 10, 2014 DOI: 10.1016/j.biopsych.2013.12.015 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | MDMA |
| Keywords | Euphoriant Cerebral blood flow Amygdala Resting State FMRI Hippocampus Hallucinogen Putamen Anesthesia |
| Citations | 182 |
| Key findings | The medial temporal lobes appear to be specifically implicated in the mechanism of action of MDMA. |
Abstract
The MTLs appear to be specifically implicated in the mechanism of action of MDMA, but further work is required to elucidate how the drug's characteristic subjective effects arise from its modulation of spontaneous brain activity.