Age-dependent (+)MDMA-mediated Neurotoxicity in Mice
María E. Reverón, Terrence J. Monks, Christine L. Duvauchelle
Neurotoxicology July 6, 2005 DOI: 10.1016/j.neuro.2005.05.006 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | 4- and 10-week-old C57Bl/6J mice |
| Intervention | (+)-MDMA |
| Dose | 20 mg/kgx4, s.c. |
| Duration | 7 days post-treatment |
| Topics | MDMA Serotonin |
| Keywords | Dopaminergic Dopamine transporter Monoamine neurotransmitter Neurotoxicity Vesicular monoamine transporter Tyrosine hydroxylase Endocrinology Striatum Pharmacology |
| Citations | 24 |
| Key findings | Older mice exhibited greater hyperthermic response to MDMA and were more susceptible to subsequent dopaminergic damage than younger mice. |
Abstract
In the present study the effects of a neurotoxic regimen of (+)-MDMA (20 mg/kgx4, s.c.) in 4- and 10-week-old C57Bl/6J mice during treatment and 7 days post-treatment were examined. Rectal temperatures monitored between (+)-MDMA injections (30 min post-injection/2 h intervals) revealed hyperthermic responses in both age groups, with the magnitude of the response significantly greater in older mice. Seven days post-treatment, immunoblot analyses of the vesicular monoamine transporter 2 (VMAT2), and tyrosine hydroxylase (TH) revealed significant reductions (-37 and -58%, respectively) in the older animals, but not in the younger group, compared to age-matched controls. Dopamine transporter (DAT) expression was significantly reduced in both 4- and 10-week-old animals (26 and 69.7%, respectively). (+)-MDMA-treated animals also exhibited significantly lower levels of striatal dopamine, and 3,4-dihydroxyphenylacetic acid than controls, again the effect being more pronounced in the older animals. Although both age groups showed evidence of (+)-MDMA-induced toxicity, our data revealed that older animals exhibited a greater hyperthermic response to (+)-MDMA and were also are more susceptible to subsequent dopaminergic damage than the younger animals.
Comparable studies
Other preclinical and animal studies on MDMA, most cited first.
Citations in the library
Cited by 12
- Neurotoxicity of MDMA: Main effects and mechanisms. Experimental Neurology October 1, 2021
- A developmental comparison of the neurobehavioral effects of ecstasy (MDMA) Neurotoxicology and Teratology October 21, 2006
- Effects of 3,4‐methylenedioxymethamphetamine (MDMA) on serotonin transporter and vesicular monoamine transporter 2 protein and gene expression in rats: implications for MDMA neurotoxicity Journal of Neurochemistry November 30, 2009
- Microglial and astroglial activation by 3,4‐methylenedioxymethamphetamine (MDMA) in mice depends on S(+) enantiomer and is associated with an increase in body temperature and motility Journal of Neurochemistry October 20, 2012
- The combined effects of 3,4-methylenedioxymethamphetamine (MDMA) and selected substituted methcathinones on measures of neurotoxicity Neurotoxicology and Teratology February 16, 2017
and 7 more in the library
Cites 14
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- Small Changes in Ambient Temperature Cause Large Changes in 3,4-Methylenedioxymethamphetamine (MDMA)-Induced Serotonin Neurotoxicity and Core Body Temperature in the Rat Journal of Neuroscience July 1, 1998
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- Age-dependent sensitivity of rats to the long-term effects of the serotonergic neurotoxicant (+/-)-3,4-methylenedioxymethamphetamine (MDMA) correlates with the magnitude of the MDMA-induced thermal response. Journal of Pharmacology and Experimental Therapeutics October 1, 1995
and 9 more in the library