Behavioural, biochemical and neurocytoarchitechural impact of MDMA in male adolescent mice
B.J Oloruntola, P.A Adeniyi, A.O. Ishola, O.O. Ogedengbe, B.P Olatunji, A.A Olabiyi, P.D Shallie
Anatomy Journal of Africa 1970 DOI: 10.4314/aja.v6i1.160450 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Randomized controlled animal experiment Peer reviewed |
|---|---|
| Sample size | 15 |
| Population | Adolescent male mice |
| Intervention | MDMA |
| Dose | 10 mg/kg and 20 mg/kg, s.c |
| Topics | MDMA |
| Key findings | Mice treated with 10 mg/kg or 20 mg/kg MDMA showed significantly lower motor activity than saline controls, along with reduced catalase and monoamine oxidase activity and cellular distortion in the cerebellum. The authors conclude that MDMA alters motor activity and neurocytoarchitecture and enzyme activity in adolescent male mice. |
Abstract
Neurotoxicity of 3, 4-Methylenedioxymethamphetamine (MDMA, ecstasy) is still controversially discussed. MDMA is an amphetamine derivative that has gained significant popularity in recent years and has become the recreational drug of choice for many young, adolescents and adults. This study sought to investigate that MDMA causes a behavioral, biochemical and neurocytoarchitechural change in male adolescent mice. Fifteen adolescent male mice were used for this study. They were randomly divided into 3 groups, of five mice each, control group received normal saline (Ctrl), 5 mice received 10 mg/kg of MDMA, s.c (LoD) and another 5 mice received 20 mg/kg of MDMA, s.c (HiD). The animals were subjected to behavioural tests to check their motor activity. Biochemical analysis to test for the level of catalase and monoamine oxidase activity was also done. The motor activity of animals treated with 10 mg/kg and 20 mg/kg of MDMA was significantly (p < 0.05) lower when compared with the control. Likewise, there was a reduction in the catalase and monoamine oxidase activity in the treated groups. In the cerebellum, cellular distortion was seen in the treated group. It could be concluded that MDMA affects the motor activity of the treated animals and thus cause an alteration in the neurocytoarchitechure, catalase and monoamine oxidase activities of the animals.Keywords: MDMA, Motor function, Hippocampus, Cerebellum, Biochemical.
Comparable studies
Other preclinical and animal studies on MDMA, most cited first.
Citations in the library
Cites 5
- Human psychopharmacology of Ecstasy (MDMA): a review of 15 years of empirical research Human Psychopharmacology: Clinical and Experimental December 1, 2001
- 3,4-methylenedioxymethamphetamine (MDMA): current perspectives Substance Abuse and Rehabilitation November 1, 2013
- Molecular and Cellular Mechanisms of Ecstasy-Induced Neurotoxicity: An Overview Molecular Neurobiology June 1, 2009
- Ecstasy (MDMA): a review of its possible persistent psychological effects Psychopharmacology September 7, 2000
- MDMA (ecstasy) inhibition of MAO type A and type B: comparisons with fenfluramine and fluoxetine (Prozac). Neuropsychopharmacology July 1994