Verbal Memory Deficits Are Correlated with Prefrontal Hypometabolism in 18FDG PET of Recreational MDMA Users
Oliver G. Bosch, Michael Wagner, Frank Jessen, Kai‐uwe Kühn, Alexius Joe, Erich Seifritz, Wolfgang Maier, Hans‐jürgen Biersack, Boris B. Quednow
PLoS One April 9, 2013 DOI: 10.1371/journal.pone.0061234 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Correlational study Peer reviewed |
|---|---|
| Population | Recreational MDMA users |
| Topics | MDMA |
| Keywords | Hippocampus Dorsolateral prefrontal cortex Verbal memory Audiology |
| Citations | 34 |
| Key points | Verbal learning and recall deficits in MDMA users are correlated with glucose hypometabolism in prefrontal and parietal cortex, and word recognition deficits are additionally correlated with mediotemporal hypometabolism. |
Abstract
Verbal learning and recall deficits of recreational MDMA users are correlated with glucose hypometabolism in prefrontal and parietal cortex, while word recognition was additionally correlated with mediotemporal hypometabolism. We conclude that memory deficits of MDMA users arise from combined fronto-parieto-mediotemporal dysfunction.
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Cites 34
- Positron emission tomographic evidence of toxic effect of MDMA (“Ecstasy”) on brain serotonin neurons in human beings The Lancet October 1, 1998
- The molecular mechanism of "ecstasy" [3,4-methylenedioxy-methamphetamine (MDMA)]: serotonin transporters are targets for MDMA-induced serotonin release. Proceedings of the National Academy of Sciences March 1, 1992
- Memory impairment in abstinent MDMA ("Ecstasy") users Neurology December 1, 1998
- Altered Serotonin Innervation Patterns in the Forebrain of Monkeys Treated with (±)3,4-Methylenedioxymethamphetamine Seven Years Previously: Factors Influencing Abnormal Recovery Journal of Neuroscience June 15, 1999
- (±3,4-Methylenedioxymethamphetamine Selectively Damages Central Serotonergic Neurons in Nonhuman Primates JAMA July 1, 1988
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