Therapeutic Potential of Natural Psychoactive Drugs for Central Nervous System Disorders: A Perspective from Polypharmacology
Current Medicinal Chemistry December 13, 2019 DOI: 10.2174/0929867326666191212103330 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | Ayahuasca Cannabis |
| Keywords | Drug Pharmacology |
| Citations | 15 |
| Key findings | Research on psychoactive drugs like ayahuasca and cannabis can be effectively combined with the polypharmacology paradigm to develop multi-target treatments for central nervous system disorders. |
Abstract
In the drug development, the formation of highly selective ligands has been unsuccessful in the treatment of central nervous system disorders. Multi-target ligands, from the polypharmacology paradigm, are being proposed as treatments for these complex disorders, since they offer enhanced efficacy and a strong safety profile. Natural products are the best examples of multi-target compounds, so they are of high interest within this paradigm. Additionally, recent research on psychoactive drugs of natural origin, such as ayahuasca and cannabis, has demonstrated the promising therapeutic potential for the treatment of some psychiatric and neurological disorders. In this text, we describe how research on psychoactive drugs can be effectively combined with the polypharmacology paradigm, providing ayahuasca and cannabis research as examples. The advantages and disadvantages are also discussed.
Comparable studies
Other narrative reviews on ayahuasca, most cited first.
Citations in the library
Cited by 5
- Biochemical Mechanisms Underlying Psychedelic-Induced Neuroplasticity. Biochemistry January 21, 2022
- Psychedelic-inspired approaches for treating neurodegenerative disorders. Journal of Neurochemistry July 1, 2022
- Communalistic use of psychoactive plants as a bridge between traditional healing practices and Western medicine: A new path for the Global Mental Health movement. Transcultural Psychiatry October 1, 2022
- Psychedelic drugs as a long-needed innovation in psychiatry Qeios April 27, 2020
- Psychedelic Medicines in Major Depression: Progress and Future Challenges. Advances in experimental medicine and biology 2021
Cites 42
- Human hallucinogen research: guidelines for safety. Journal of Psychopharmacology July 1, 2008
- Psychedelics Promote Structural and Functional Neural Plasticity Cell Reports June 1, 2018
- Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial Psychological Medicine June 15, 2018
- Safety and Efficacy of Lysergic Acid Diethylamide-Assisted Psychotherapy for Anxiety Associated With Life-threatening Diseases The Journal of Nervous and Mental Disease March 4, 2014
- Acute, subacute and long-term subjective effects of psilocybin in healthy humans: a pooled analysis of experimental studies Journal of Psychopharmacology September 20, 2010
and 37 more in the library