LSD produces place preference and flavor avoidance but does not produce flavor aversion in rats.
Behavioral Neuroscience 1996 DOI: 10.1037//0735-7044.110.3.503 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats (implied by typical place conditioning and taste reactivity paradigms) |
| Intervention | Lysergic acid diethylamide (LSD) |
| Dose | 0.05 to 0.2 mg/kg |
| Topics | Addiction LSD Serotonin |
| Keywords | Conditioning Flavor Taste aversion Conditioned place preference Preference test Reactivity psychology Pharmacology Food science Biochemistry |
| Citations | 41 |
| Key findings | LSD produces conditioned place preference only at the highest dose (0.2 mg/kg) and induces taste avoidance without producing taste aversion, suggesting a mechanism distinct from emetic drugs. |
Abstract
The hedonic properties of lysergic acid diethylamide (LSD) were assessed using the place conditioning, taste reactivity, and taste avoidance tests. LSD produced a conditioned place preference, but only at the highest dose tested (0.2 mg/kg). A single preexposure to the conditioning chamber (latent inhibition) prevented the establishment of a place preference. When paired with sucrose, doses of 0.05 to 0.2 mg/kg of LSD produced taste avoidance, but no dose of LSD produced an aversion to the taste as assessed by the taste reactivity test. These results suggest that LSD, like other rewarding drugs, produces taste avoidance by a mechanism other than that produced by emetic drugs.