Determination and Confirmation of Psychedelic and Psychoactive Compounds in Botanical Materials by UPLC-ESI-MS/MS: Single-Laboratory Validation.
Torey French, Anthony J Fontana, Robert LaBudde, Sharon L Brunelle, Sidney Sudberg
J AOAC Int January 1, 2026 DOI: 10.1093/jaoacint/qsaf081 (opens in new tab) via PubMed Central
Summary
AI-generated from the abstractA single-laboratory validation study developed and confirmed a method using ultra-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC-ESI-MS/MS) to detect and quantify psychedelic and psychoactive compounds in botanical materials. The method was validated for specificity, accuracy, precision, and sensitivity, demonstrating its reliability for identifying these substances in plant samples. No specific numerical results or sample sizes are reported in the abstract.
Study at a glance
| Characteristics | Single-laboratory validation Peer reviewed |
|---|---|
| Citations | 1 |
| Key finding | A validated UPLC-ESI-MS/MS method reliably determines and confirms psychedelic and psychoactive compounds in botanical materials. |
Abstract
Determination and Confirmation of Psychedelic and Psychoactive Compounds in Botanical Materials by UPLC-ESI-MS/MS: Single-Laboratory Validation.