Determination and Confirmation of Psychedelic and Psychoactive Compounds in Botanical Materials by UPLC-ESI-MS/MS: Single-Laboratory Validation.
J AOAC Int January 1, 2026 Torey French, Anthony J Fontana, Robert LaBudde et al. 1 citation
A single-laboratory validation study developed and confirmed a method using ultra-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC-ESI-MS/MS) to detect and quantify psychedelic and psychoactive compounds in botanical materials. The method was validated for specificity, accuracy, precision, and sensitivity, demonstrating its reliability for identifying these substances in plant samples. No specific numerical results or sample sizes are reported in the abstract.