Choosing Between Ketamine and Electroconvulsive Therapy for Outpatients With Treatment-Resistant Depression—Advantage Ketamine?
Sanjay J. Mathew, Manish K. Jha, Amit Anand
JAMA Psychiatry December 1, 2023 DOI: 10.1001/jamapsychiatry.2023.3979 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Viewpoint Peer reviewed |
|---|---|
| Interventions | Electroconvulsive therapy Ketamine |
| Topics | Depression Esketamine Ketamine |
| Citations | 8 |
| Key points | Neither ECT nor ketamine is clearly superior for all patients with treatment-resistant depression; the choice depends on individual circumstances and preferences. |
Abstract
This Viewpoint examines key issues stemming from several recent reports of electroconvulsive therapy (ECT) vs ketamine for improving depressive symptoms in treatment-resistant depression (TRD).
Citations in the library
Cited by 5
- Are “mystical experiences” essential for antidepressant actions of ketamine and the classic psychedelics? European Archives of Psychiatry and Clinical Neuroscience February 27, 2024
- Number needed to treat (NNT) for ketamine and esketamine in adults with treatment-resistant depression: A systematic review and meta-analysis. Journal of Affective Disorders July 1, 2024
- Ketamine vs Electroconvulsive Therapy for Treatment-Resistant Depression: A Secondary Analysis of a Randomized Clinical Trial. JAMA Network Open June 3, 2024
- Comparative Efficacy and Safety of Ketamine Versus Electroconvulsive Therapy in Major Depressive Disorder: A Meta-Analysis of Randomized Controlled Trials. Psychiatric Quarterly February 18, 2025
- Impact analysis of expanded access to ketamine for treatment-resistant depression. Journal of comparative effectiveness research June 1, 2025
Cites 6
- A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression Archives of General Psychiatry August 1, 2006
- Ketamine versus ECT for Nonpsychotic Treatment-Resistant Major Depression. New England Journal of Medicine May 24, 2023
- Efficacy and Safety of Ketamine vs Electroconvulsive Therapy Among Patients With Major Depressive Episode: A Systematic Review and Meta-analysis. JAMA Psychiatry October 19, 2022
- Racemic Ketamine as an Alternative to Electroconvulsive Therapy for Unipolar Depression: A Randomized, Open-Label, Non-Inferiority Trial (KetECT) The International Journal of Neuropsychopharmacology December 4, 2021
- Ketamine vs Electroconvulsive Therapy for Major Depressive Episode JAMA Psychiatry June 1, 2023
and 1 more in the library