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Choosing Between Ketamine and Electroconvulsive Therapy for Outpatients With Treatment-Resistant Depression—Advantage Ketamine?

Sanjay J. Mathew, Manish K. Jha, Amit Anand

JAMA Psychiatry December 1, 2023 DOI: 10.1001/jamapsychiatry.2023.3979 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Viewpoint Peer reviewed
Interventions Electroconvulsive therapy Ketamine
Topics Depression Esketamine Ketamine
Citations 8
Key points Neither ECT nor ketamine is clearly superior for all patients with treatment-resistant depression; the choice depends on individual circumstances and preferences.

Abstract

This Viewpoint examines key issues stemming from several recent reports of electroconvulsive therapy (ECT) vs ketamine for improving depressive symptoms in treatment-resistant depression (TRD).