[Identification of Three Arylcyclohexylamines (MXPr, MXiPr, and DMXE) in Illegal Products].
Rie Tanaka, Maiko Kawamura, Sakumi Mizutani, Takashi Hakamatsuka, Ruri Kikura-Hanajiri
Yakugaku Zasshi 2022 DOI: 10.1248/yakushi.21-00235 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Analytical identification study Peer reviewed |
|---|---|
| Keywords | Arylcyclohexylamine Deoxymethoxetamine Methoxisopropamine Methoxpropamine New psychoactive substance |
| Citations | 3 |
| Key points | Three MXE derivatives—MXPr, MXiPr, and DMXE—were identified in illegal products in Japan. |
Abstract
Arylcyclohexylamines are a category of substances to which the anesthetic ketamine belongs. The arylcyclohexylamines have been reported to act as antagonists of the N-methyl-d-aspartate (NMDA) receptor. An analog of ketamine, 2-(ethylamino)-2-(3-methoxyphenyl)-cyclohexanone (methoxetamine; MXE), has been controlled as a narcotic in Japan and overdoses of MXE have been reported to cause health problems. In recent years, MXE derivatives have beendetected in illegal products in Japan. In this study, we describe the identification of three MXE derivatives, 2-(3-methoxyphenyl)-2-(propylamino)cyclohexan-1-one (methoxpropamine; MXPr), 2-(isopropylamino)-2-(3-methoxyphenyl)cyclohexan-1-one (methoxisopropamine; MXiPr) and 2-(3-methoxyphenyl)-2-(propylamino)cyclohexan-1-one (deoxymethoxetamine; DMXE), from illegal products.
Citations in the library
Cited by 2
- Derivatives of methoxetamine and major methoxetamine metabolites potently block NMDA receptors. Journal of Pharmacological Sciences December 1, 2022
- Contamination and Structural Analogs in the Illicit Phencyclidine Market: Pharmacology, Toxicology, and Public Health Implications of PCE, TCP, 3-MeO-PCP, and Fentanyl Adulteration
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